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Mycobacterial tuberculosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Apoptosis (1) Bacterial (20) Biochemical Assay Reagents (1) Calcium Channel (3) DNA/RNA Synthesis (1) Drug Metabolite (3) Endogenous Metabolite (1) Interleukin Related (1) P-glycoprotein (3) Potassium Channel (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Infection (20) Inflammation/Immunology (5)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1046

Clofazimine Maximum Cited Publications 6 Publications Verification	Bacterial Antibiotic DNA/RNA Synthesis Interleukin Related Apoptosis	Infection Inflammation/Immunology Cancer
Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and *tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication* and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .

HY-P3270

Capreomycin	Bacterial Antibiotic	Infection
Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation

HY-117145

Thiophene-2	Bacterial	Infection
Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity .

HY-120884

InhA-IN-5

Bacterial Infection

InhA-IN-5 (compound 1) is a potent Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA) inhibitor .

InhA-IN-5	Bacterial	Infection
InhA-IN-5 (compound 1) is a potent Mycobacterial tuberculosis (Mtb) trans-2-enoyl-acyl carrier protein reductase (InhA) inhibitor .

HY-152035

Mycobacterial Zmp1-IN-1	Bacterial	Infection Inflammation/Immunology
Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB) .

HY-142031

4-Piperidinecarboxamide	Bacterial	Infection
4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor. 4-Piperidinecarboxamide is a promising anti-tuberculosis (TB) agent .

HY-150967

MmpL3-IN-1	Bacterial	Infection
MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis .

HY-151356

Antibacterial agent 122	Bacterial	Infection
Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies .

HY-109588

NITD-349 1 Publications Verification	Bacterial	Infection
NITD-349 is an MmpL3 inhibitor that shows highly potent anti-mycobacterial activity with MIC₅₀ of 23 nM against virulent Mycobacterium tuberculosis H37Rv.

HY-151354

Antibacterial agent 121	Bacterial	Infection
Antibacterial agent 121 (Compound 10) is an antibacterial agent. Antibacterial agent 121 shows anti-mycobacterial and anti-inflammatory activities and can be used in Tuberculosis (TB) research .

HY-109587

BM635

Bacterial Infection

BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC₅₀ of 0.12 μM against M. tuberculosis H37Rv.

BM635	Bacterial	Infection
BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC₅₀ of 0.12 μM against M. tuberculosis H37Rv.

HY-146158

WX-081	Bacterial Potassium Channel Antibiotic	Infection
WX-081, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. WX-081 exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. WX-081 also inhibits hERG channel with the IC50 of 1.89 μM.

HY-100725

BM212 3 Publications Verification	Bacterial	Infection
BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM .

HY-151205

Antituberculosis agent-3	Bacterial	Infection Inflammation/Immunology
Antituberculosis agent-3 (Compound 2) is an antituberculosis agent. Antituberculosis agent-3 shows anti-mycobacterial activity, and can inhibit M. tuberculosis H37Rv strain growth (MIC=12.5 μg/mL) .

HY-109587B

BM635 mesylate	Bacterial	Infection
BM635 mesylate is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 mesylate has a MIC₅₀ of 0.6 μM against M. tuberculosis H37Rv. BM635 mesylate significantly improves the bioavailability compared to free-base BM635 .

HY-109587A

BM635 hydrochloride	Bacterial	Infection
BM635 hydrochloride is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 hydrochloride has an MIC₅₀ of 0.08 μM against M.tuberculosis H37Rv. BM635 hydrochloride doubles the in vivo exposure with respect to the free base BM635 .

HY-151204

PknB-IN-1	Bacterial	Infection Inflammation/Immunology
PknB-IN-1 (Compound 2) is a protein kinase B (PknB) inhibitor (IC₅₀=14.4 μM). PknB-IN-1 shows anti-mycobacterial activity, can inhibit M. tuberculosis H37Rv strain growth (MIC=6.2 μg/mL) .

HY-120733

Calpinactam FKI-4905	Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .

HY-147704

Antimycobacterial agent-2	Bacterial	Infection
Antimycobacterial agent-2 (compound 58) is a potent antimycobacterial agent. Antimycobacterial agent-2 shows anti-mycobacterial activities with an MIC₉₉ of 0.8 µM for Mycobacterium tuberculosis* (M.tb) H37Rv. Antimycobacterial agent-2 shows cytotoxic activities with an IC₅₀* of48.1 µM for CHO cells .

HY-100750

Norverapamil hydrochloride 1 Publications Verification (±)-Norverapamil hydrochloride; D591 hydrochloride	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-135328

Norverapamil (±)-Norverapamil; D591	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor .

HY-122643

NITD-916	Bacterial	Infection
NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC₅₀ of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects .

HY-135328S

Norverapamil-d7 (±)-Norverapamil-d₇; D591-d₇	Calcium Channel P-glycoprotein Drug Metabolite	Cardiovascular Disease
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

HY-W250306

Carbol fuchsin	Biochemical Assay Reagents	Others
Carbol fuchsin is a histological stain used in microbiology to distinguish acid-fast bacteria from non-acid-fast bacteria. It is a mixture of basic fuchsin, phenol, and water and is commonly used in the Ziehl-Neelsen staining technique for the detection of tuberculosis and other mycobacterial infections. Carbol fuchsin stains the cell walls of acid-fast bacteria bright red, while other cells are unstained or slightly stained. This makes it easier to see and identify these microbes under a microscope. Carbol fuchsin is also used in veterinary medicine and phytopathology for similar purposes.

Clofazimine 5+ Cited Publications	Chromogenic Assays
Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and *tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication* and inhibiting IL2 (IC₅₀ = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research .

Carbol fuchsin	Dyes
Carbol fuchsin is a histological stain used in microbiology to distinguish acid-fast bacteria from non-acid-fast bacteria. It is a mixture of basic fuchsin, phenol, and water and is commonly used in the Ziehl-Neelsen staining technique for the detection of tuberculosis and other mycobacterial infections. Carbol fuchsin stains the cell walls of acid-fast bacteria bright red, while other cells are unstained or slightly stained. This makes it easier to see and identify these microbes under a microscope. Carbol fuchsin is also used in veterinary medicine and phytopathology for similar purposes.

Capreomycin	Bacterial Antibiotic	Infection
Capreomycin is a macrocyclic peptide antibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-120733

Calpinactam FKI-4905	Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology	Bacterial Endogenous Metabolite
Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .

Cat. No.	Product Name	Chemical Structure

HY-135328S

Norverapamil-d7
Norverapamil-d₇ is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor[1][2].

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Mycobacterial tuberculosis

Inhibitors & Agonists

Fluorescent Dye

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products